Geir B. Risvoll
Dept. of Electrical Engineering and Computer Science, University of Stavanger, Norway
Tormod Drengstig
Dept. of Electrical Engineering and Computer Science, University of Stavanger, Norway
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http://dx.doi.org/10.3384/ecp17138343Published in: Proceedings of the 58th Conference on Simulation and Modelling (SIMS 58) Reykjavik, Iceland, September 25th – 27th, 2017
Linköping Electronic Conference Proceedings 138:45, p. 343-349
Published: 2017-09-27
ISBN: 978-91-7685-417-4
ISSN: 1650-3686 (print), 1650-3740 (online)
In this paper we investigate how the disturbance rejection
properties of physiological regulatory systems depend on
the signalling kinetics between the biochemical species
being considered as controlled and manipulated variables.
Based on the mathematical model of a physiological regulatory
system, we analyse the impact of three different signalling
models, i.e. linear signalling, first order and second
order Hill kinetics. We separate the analysis in two parts.
First we identify to what extend the signalling from the
manipulated variable to the controlled variable affect the
range and ratio of manageable disturbances. In the second
part we investigate whether and how the signalling from
the controlled variable to the manipulated variable will affect
the parameters of the controller part of the regulatory
system. In this context, saturable Hill kinetics display advantages
compared to linear signalling.
