Conference article

Modeling and Simulation of Triclosan Kinetics and Distribution in Humans Using a PBPK Model

Samee Maharjan
Telemark University College, Norway

Roshan Sharma
Telemark University College, Norway

Trine Husøy
Dept. of Food, Water and Cosmetics; Norwegian Institute of Public Health (NIPH)

Hubert Dirven
Dept. of Food, Water and Cosmetics; Norwegian Institute of Public Health (NIPH)

Monica Andreassen
Dept. of Food, Water and Cosmetics; Norwegian Institute of Public Health (NIPH)

Bernt Lie
Telemark University College, Norway

Download articlehttp://dx.doi.org/10.3384/ecp15119279

Published in: Proceedings of the 56th Conference on Simulation and Modelling (SIMS 56), October, 7-9, 2015, Linköping University, Sweden

Linköping Electronic Conference Proceedings 119:28, s. 279-288

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Published: 2015-11-25

ISBN: 978-91-7685-900-1

ISSN: 1650-3686 (print), 1650-3740 (online)

Abstract

Personal care products (PCPs) such as soaps, perfumes, toothpastes, lotions, etc. contain various chemicals. Triclosan (TCS) is widely used as an antibacterial additive in PCPs. Traces of TCS are found in human plasma and milk indicating absorption through the skin and/or after oral ingestion. In this paper, a Physiologically Based Pharmacokinetic or Toxicokinetic (PBPK/TK) model is developed to assess the behavior of TCS in human body after exposure to PCPs orally or through the skin. The model will describe metabolism, kinetics and distribution in human organs. The developed model is based on available literature data on biotransformation in rodents and humans, and is simulated using MATLAB and/or Modelica. The intention of the work is to further develop the model and fit model parameters to experimental data, and to develop a PBPK model useful for human risk assessment of TCS.

Keywords

Modeling; Simulation; PBPK; Triclosan; Kinetics; Distribution; Humans

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