Conference article

Integrative physiology in Modelica

Jirí Kofránek
Department of Pathophysiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic

Tomáš Kulhánek
Department of Pathophysiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic

MareK Mateják
Department of Pathophysiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic

Filip Ježek
Department of Pathophysiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic

Jan Šilar
Department of Pathophysiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic

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Published in: Proceedings of the 12th International Modelica Conference, Prague, Czech Republic, May 15-17, 2017

Linköping Electronic Conference Proceedings 132:66, p. 589-603

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Published: 2017-07-04

ISBN: 978-91-7685-575-1

ISSN: 1650-3686 (print), 1650-3740 (online)


The integrative model of human physiology connects individual physiological subsystems into a single unit. They are very large (contain thousands of variables) and represent a formalized description of interconnected physiological regulations. The issue of formalization of physiological systems became part of a series of international projects (e.g. the worldwide program "PHYSIOME", or the European program "VIRTUAL PHYSIOLOGICAL HUMAN"). The development of large-scale models of human physiology was facilitated by a new generation (i.e. equation-based) simulation environment, especially by Modelica language. These models can be used to explain the causal relations of the pathogenesis of many diseases, they can be applied in the evaluation of clinical trials and they can also be used in the core of sophisticated medical simulators.


Simulation, Physiology, Integrative models


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