Conference article

The impact of signalling kinetics on controller motif performance

Geir B. Risvoll
Dept. of Electrical Engineering and Computer Science, University of Stavanger, Norway

Tormod Drengstig
Dept. of Electrical Engineering and Computer Science, University of Stavanger, Norway

Download articlehttp://dx.doi.org/10.3384/ecp17138343

Published in: Proceedings of the 58th Conference on Simulation and Modelling (SIMS 58) Reykjavik, Iceland, September 25th – 27th, 2017

Linköping Electronic Conference Proceedings 138:45, p. 343-349

Show more +

Published: 2017-09-27

ISBN: 978-91-7685-417-4

ISSN: 1650-3686 (print), 1650-3740 (online)

Abstract

In this paper we investigate how the disturbance rejection properties of physiological regulatory systems depend on the signalling kinetics between the biochemical species being considered as controlled and manipulated variables. Based on the mathematical model of a physiological regulatory system, we analyse the impact of three different signalling models, i.e. linear signalling, first order and second order Hill kinetics. We separate the analysis in two parts. First we identify to what extend the signalling from the manipulated variable to the controlled variable affect the range and ratio of manageable disturbances. In the second part we investigate whether and how the signalling from the controlled variable to the manipulated variable will affect the parameters of the controller part of the regulatory system. In this context, saturable Hill kinetics display advantages compared to linear signalling.

Keywords

Systems Biology, Control Engineering, Homoeostasis, Signalling Kinetics

References

No references available

Citations in Crossref