Atya Elsheikh
Research Center Jülich, Institute of Biotechnology, Germany
Katharina Nöh
Research Center Jülich, Institute of Biotechnology, Germany
Eric von Lieres
Research Center Jülich, Institute of Biotechnology, Germany
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http://dx.doi.org/10.3384/ecp09430039Published in: Proceedings of the 7th International Modelica Conference; Como; Italy; 20-22 September 2009
Linköping Electronic Conference Proceedings 43:6, p. 47-55
Published: 2009-12-29
ISBN: 978-91-7393-513-5
ISSN: 1650-3686 (print), 1650-3740 (online)
Derivative-based optimization methods for parameter estimation require good start values in order to converge to the global optimum. A conventional multistart strategy is often not practical for identifying such start values; especially for high dimensional problems. Moreover; the computational efforts for each iteration of the optimizer are significantly increased by the computation of parameter sensitivities. We hence present a multistart recursive clustering strategy that utilizes DAE decomposition algorithms; in particular Tarjan’s and tearing algorithms. These algorithms are also used by standard Modelica compilers for improving the performance of solving large DAE systems. Our key concept
is to provide a natural decomposition of the parameter estimation problem into smaller clusters (i.e. subproblems); each of which requires fewer start values and less computation. The resulting local minima are taken as start values for enlarged subproblems; and so forth until good start values for the original problem are found. This approach serves to improve global convergence and computational speed of multistart derivative-based optimization strategies for large sparse DAE systems.
Parameter estimation; global optimization; cluster methods; DAE decomposition algorithms