Conference article

Modelling a Bacterimss Life: A Petrin-Net Library in Modelica

Sabrina Pross
University of Applied Sciences, Germany

Bernhard Bachmann
University of Applied Sciences, Germany

Ralf Hofestädt
Bielefeld University, Germany

Karsten Niehaus
Bielefeld University, Germany

Rainer Ueckerdt
University of Applied Sciences, Germany

Frank-Jörg Vorhölter
Bielefeld University, Germany

Petra Lutter
Bielefeld University, Germany

Download articlehttp://dx.doi.org/10.3384/ecp09430015

Published in: Proceedings of the 7th International Modelica Conference; Como; Italy; 20-22 September 2009

Linköping Electronic Conference Proceedings 43:51, s. 463-472

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Published: 2009-12-29

ISBN: 978-91-7393-513-5

ISSN: 1650-3686 (print), 1650-3740 (online)

Abstract

For modeling biological systems the already existing Petri Net Libraries were further developed with OpenModelica using the SimForge graphical user interface (GUI). The Petri Nets elements were wrapped into models for different reaction types to simplify the modeling process. Additionally; a database connection was implemented for integrating kinetic data. The application of this new Reaction Library is demonstrated by the xanthan production of the bacterium Xanthomonas campestris pv. campestris. A mathematical model is introduced to predict growth and xanthan production; given an initial glucose concentration. The parameters of this model are estimated with the aid of the Optimization Toolbox in MATLAB.

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