Optimization of Bioreactor Volumes in Steady-State - A Simulation Study

Hanna Molin
Department of Information Technology, Uppsala University, Uppsala, Sweden

Jesús Zambrano
School of Business, Society and Engineering, Mälardalen University, Västerås, Sweden

Bengt Carlsson
Department of Information Technology, Uppsala University, Uppsala, Sweden

Ladda ner artikelhttp://dx.doi.org/10.3384/ecp18153322

Ingår i: Proceedings of The 59th Conference on Simulation and Modelling (SIMS 59), 26-28 September 2018, Oslo Metropolitan University, Norway

Linköping Electronic Conference Proceedings 153:46, s. 322-327

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Publicerad: 2018-11-19

ISBN: 978-91-7685-494-5

ISSN: 1650-3686 (tryckt), 1650-3740 (online)


This work deals with the analysis and design of bioreactors formed by a number of completely stirred tank reactors (CSTRs) in series. The model includes three main components: the concentration of one dominant particulate biomass, one soluble substrate component and one particulate inert matter. The model is analyzed in steadystate conditions. Monod kinetics is used for describing the specific growth rate, and the decay rate of the biomass is included. Two main optimization problems were studied: (i) minimize the effluent substrate concentration for a given total volume, and (ii) minimize the total volume for a given effluent substrate concentration. An alternative to optimize a large number of CSTRs is to consider the asymptotic case of one CSTR followed by a plug-flow reactor (PFR). Numerical results show that there is an optimal volume distribution for the two configurations in each optimization problem.


Bioreactor optimization, completely stirred tank, effluent minimization, plug-flow reactor.


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