Konferensartikel

In this paper we investigate how the disturbance rejection properties of physiological regulatory systems depend on the signalling kinetics between the biochemical species being considered as controlled and manipulated variables. Based on the mathematical model of a physiological regulatory system, we analyse the impact of three different signalling models, i.e. linear signalling, first order and second order Hill kinetics. We separate the analysis in two parts. First we identify to what extend the signalling from the manipulated variable to the controlled variable affect the range and ratio of manageable disturbances. In the second part we investigate whether and how the signalling from the controlled variable to the manipulated variable will affect the parameters of the controller part of the regulatory system. In this context, saturable Hill kinetics display advantages compared to linear signalling.

Systems Biology, Control Engineering, Homoeostasis, Signalling Kinetics